منابع مشابه
Changes in induced regulatory T cells by interleukin 35 during atopic dermatitis*
It was with great interest that I read the recently published, brief communication by Roesner et al., which analyzed the circulation frequency of forkhead box P3 (Foxp3)+ regulatory T cells (Tregs) in adult patients with atopic dermatitis (AD).1 The study found a positive correlation between these cells and disease severity. Recently, several researchers have focused on the relatively newly ide...
متن کاملInterleukin-35 administration counteracts established murine type 1 diabetes – possible involvement of regulatory T cells
The anti-inflammatory cytokine IL-35 is produced by regulatory T (Treg) cells to suppress autoimmune and inflammatory responses. The role of IL-35 in type 1 diabetes (T1D) remains to be answered. To elucidate this, we investigated the kinetics of Treg cell response in the multiple low dose streptozotocin induced (MLDSTZ) T1D model and measured the levels of IL-35 in human T1D patients. We found...
متن کاملInterleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens
Impaired regulatory B cell (Breg) responses are associated with several autoimmune diseases in humans; however, the role of Bregs in type 1 diabetes (T1D) remains unclear. We hypothesized that naturally occurring, interleukin-10 (IL-10)-producing Bregs maintain tolerance to islet autoantigens, and that hyperglycemic nonobese diabetic (NOD) mice and T1D patients lack these potent negative regula...
متن کاملRegulatory B-Cells in Transplantation
B-cells have been long accepted as the main cellular component in humoral responses. Their effector function is based on antibody and cytokine production. The development of donor-specific antibodies by B-cells has deleterious consequences in graft and patients survival. Recently, a new subset of IL-10-secreting B-cells with regulatory capacity in allergic and autoimmune diseases has been shown...
متن کاملdecreased circulating interleukin-35 levels are related to interleukin-4-producing cd8+ t cells in patients with allergic asthma
interleukin (il)-35 is a newly discovered suppressive cytokine and has been shown to alleviate inflammatory and autoimmune diseases. the purpose of this study was to investigate immunomodulatory capacity of il-35 in patients with allergic asthma.il-35 mrna expression levels in peripheral blood mononuclear cells (pbmcs) were detected by quantitative real-time pcr (qpcr). the fr...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2021
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2020.07.019